Jason,
Hendry's Beach use to have a problem with bacteria in the water coming in from the slough, but that's the only health risk I've heard of lately in this area. You might wnat to avoid slough mouths just to be safe. Plus there will be a lot of debris in the water, and mud (which the white seabass might like...). Goleta Beach would probably be pretty safe, the harbor would be fine, I'd stay away from tijiguas also.
-Brian